Biomedical Engineering University Of Arizona – UA Engineers Zero In on Ovarian Cancer Jennifer Barton is identifying biomarkers and developing diagnostic tools to detect a type of cancer often referred to as the “silent killer” of women.
University of Arizona researcher Jennifer Barton is leading a $1 million, two-year project funded by the National Cancer Institute to explore the picture of ovarian cancer, the most common gynecological cancer in the United States.
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This work could lead to the first effective screening process for ovarian cancer, said Barton, interim director of the UA’s BIO5 Institute.
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Because there are few early symptoms and no good diagnostic methods, it is present in the body; Ovarian cancer is still difficult to understand. It’s even worse,” Biomedical Engineer, Electrical and Computer Engineering; said Barton, professor of visual science and agriculture. . Biosystems Engineering;
In fact, 70 percent of women with advanced ovarian cancer have spread to other organs besides the fallopian tubes and ovaries, he said.
Physiology medical imaging; Collaborating with UA researchers in obstetrics and gynecology, Barton developed biomarkers; or undergoing specific changes in the body that can be detected by sensitive imaging techniques. for ovarian cancer in mice; Mice often model disease by spontaneously developing ovarian tumors in postmenopausal women.
Three modern imaging techniques – optical coherence tomography; Fluorescence imaging and multiphoton microscopy – Researchers take in vivo images of animal ovaries and endometrial glands to study physical and biochemical changes over time. Map the changes that occur in ovarian cancer.
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“This gives us a very controlled way to look at ovarian cancer,” Barton said. “We can observe improvements in a few months that would take years in women with the disease.”
Researchers will develop countermeasures to investigate cell surface expression that can be targeted to increase imaging sensitivity.
“Our goal is to develop a critical imaging technique to identify biomarkers in the earliest possible stages of ovarian cancer that can lead to early detection and save lives,” said Barton. “We believe that at the beginning of ovarian cancer growth, there are clusters of cells in the matrix with abnormal microstructure and fluorescence. We believe that we can identify these cells from spreading to the ovary.”
Evan Unger, a UA radiology and bioengineering professor who co-leads the cancer imaging program at the Arizona Cancer Center with Dr. Barton, said predictive biomarkers will open the door to better and more powerful identification of women in groups at risk for ovarian cancer. Research using a non-destructive or minimally invasive method such as the microendoscope Dr. Barton.”
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Barton’s small; A highly flexible endoscope or falloposcope is an imaging device that combines several probes. Tests can detect ovarian cancer in the colon, where most researchers believe the cancer started. His team has already tested solid models in clinical trials, but the new flexible cutout will make it easier for research.
Ovarian cancer can often be successfully treated with surgery and chemotherapy when detected early. But due to a lack of good early detection tools, less than half of women diagnosed survive five years.
Women who had a pelvic ultrasound or blood test for the CA-125 protein were at least slightly more likely to die. Women who don’t are more likely to die from breast cancer than women who don’t. In addition, Women have no known risk factors, such as family history or BRCA gene mutations.
According to the Centers for Disease Control and Prevention, about 20,000 American women are diagnosed with ovarian cancer each year, and 14,000 die from the disease.
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At age 30, during a visit to a specialist, an ultrasound scan revealed a large mass on her left ovary. A few weeks later, while preparing for surgery, she discovered she was pregnant. The patient’s ovaries were removed and a biopsy was performed, which confirmed the early stage of ovarian cancer. She now gave birth to a healthy young son, Ryan.
Mitstifer, a medical doctor for the Federal Bureau of Prisons, is approaching his 14th year without evidence of disease. She serves on the board of the National Ovarian Cancer Coalition and the Survivors Teaching Students: Saving Women’s Lives program; Survivors of ovarian cancer participated in the Ovarian Cancer National Alliance, a program of the Ovarian Cancer National Alliance, where they shared their stories with UA medical students.
“I have lost many friends to this terrible disease and many friends have died from it,” he said. “Many of them really want to see progress in research and treatment, and ultimately a cure,” he said. That way their kids won’t have to go through what they have and will get a good start with their studies.
Jennifer Barton is studying ovarian tumors in mice to develop the first effective diagnostic method for the disease.
Ua Engineers Zero In On Ovarian Cancer
This research was supported by the National Cancer Institute of the National Institutes of Health under Grant Number 1R01CA195723-01.
Save the date: The Tucson chapter of the National Ovarian Cancer Coalition is holding its first peace walk on Nov. 6. It will be held at the UA Mall from 8 a.m. to noon. Email [email protected] for more information.
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Get the latest University of Arizona news delivered to your inbox. Or stay in the loop using our Amazon Alexa skill. Sarah Stabenfeldt has been named one of the most influential leaders in her field by the American Institute for Medical and Biological Engineering College of Fellows.
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Sarah Stabenfeldt, assistant professor of biomedical engineering in the Ira A. Fulton Schools of Engineering at Arizona State University, has been named to the American Institute for Medical and Biological Engineering College of Fellows for her significant contributions to neural tissue engineering. Nanoparticles. Discovery of biomarkers in treatment and brain injury. Documentary photos taken before the general and face coverage of the current pandemic. Photo: Marco-Alexis Chaira/ASU
Biomedical engineers play an important role in the health of our society. By contributing new knowledge and technologies in biology and medicine, they can address some of the greatest challenges facing humanity, including addressing the effects of injury and disease.
Sarah Stabenfeldt, assistant professor of biomedical engineering in the Ira A. Fulton Schools of Engineering at Arizona State University, and neural tissue engineering. Regenerative Medicine He is a researcher who supports the discovery of nanoparticle therapies and markers called biomarkers. Healing. .
This important work led Stabenfeldt to be named in the top 2% of medical and biological engineers in the country by selection by the College of Fellows of the American Institute for Medical and Biological Engineering, or AIMBE.
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“I am very humbled to be included in this prestigious society,” Stabenfeldt said. “A lot of my mentors and role models are the Uso’s. Their friends know that I’m more successful than I ever thought I’d be.
AIMBE Engineering; Academics in society that promote medicine and biomedicine. government A non-profit organization serving the industry and scientific community. This includes research support from government agencies; Advocates academic communications on public policy and development.
“Each of these activities is very important to be involved in as a researcher and teacher,” said Stabenfeldt, a professor in the School of Biology and Health Systems Engineering at seven Fulton schools and who holds additional positions in the ASU School of Life. Science.
Engineering and medical school seats in the institution’s staff college; Research Directors; professors, Innovators and medical and biological research; It includes 2,000 people representing outstanding business people in business and academia.
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Stabenfeldt won the Nobel Prize; In addition to the Presidential Medal of Science and the Presidential Medal of Technology and Innovation, the National Engineer Members of the Academies of Medicine and Sciences are included.
New Fellows are selected by their peers who are members of the AIMBE College of Fellows. Evaluated and selected.
Stabenfeldt’s multidisciplinary approach to the discovery and development of novel biomarkers and therapeutics for traumatic brain injury is unique to AIMBE colleagues – as are his achievements and recognition from local and national institutions.
He received the National Institutes of Health Innovator Award; He has received several new investigator awards, including the National Science Foundation CAREER Award and the Arizona Biomedical Research Commission Early Stage Investigator Award. The success of Stabenfeldt’s early career was supported by his pursuit of compelling research questions and continued funding from the National Institutes of Health and the Arizona Biomedical Research Commission.
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He taught post-doctoral students; postdoctoral students and his lab; Led a group of graduate and undergraduate research students in the Stabenfeldt Lab, developing innovative strategies for nerve injury.
Fulton schools and community organizations in the Phoenix area are “instrumental in this success,” he said. “From helping with infrastructure to working with amazing students and faculty, I feel fortunate to be surrounded by a supportive community.”
AIMBE Fellows also give back and donate their land.
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