How To Lower Ldl Cholesterol With Medication
How To Lower Ldl Cholesterol With Medication – Trenton, N.J. — U.S. regulators on Friday approved a new cholesterol-lowering drug for millions of people who can’t tolerate it — or haven’t learned from widely used drugs like Lipitor and Crestor.
The U.S. Food and Drug Administration has approved Esperion Therapeutics Inc.’s Nexletol for people who are genetically predisposed to high cholesterol and have heart disease and need to further lower bad cholesterol. The daily pill should be taken with a healthy diet and the highest dose of statins a patient can tolerate, the FDA said.
How To Lower Ldl Cholesterol With Medication
High LDL, or bad cholesterol, is one of the biggest risk factors for heart attack and other problems. Studies have shown that Nexletol can lower LDL by approximately 25% when taken alone and an additional 18% when combined with a statin.
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“It’s a good option” from statistics, but those drugs will still be the first choice, said Dr. Christy Ballantyne, a cardiologist at Baylor College of Medicine. He recommends Esperion and helps diagnose medications.
Millions of people take cheap generic statins, but the drugs don’t lower LDL cholesterol enough, and many patients experience other side effects, such as muscle pain. Other options include Zetia pills, which cost between $13 and $50 per month.
Patients with Repata and Pralunt cost $6,000 or more annually. Insurance companies often limit coverage to these medications, which patients take once or twice a month.
Ann Arbor, Mich. Although Esperion did not immediately disclose the list price of the drug, it previously said it plans to sell it for around $300 a month. Nexletol, also known as bempedoic acid, should be available by the end of March, the company said.
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It works in the liver by blocking the enzyme needed to make LDL. Statins block the production of cholesterol in the liver, but in a different way, these drugs together reduce LDL more.
Dr. Manesh Patel, executive director of the Duke Heart Center, said it would be “a valuable addition to therapy” for patients who cannot lower LDL levels sufficiently with existing drugs or cannot afford injections. Patel, who was not involved in the study, estimated that 10% to 15% of his patients would be eligible for Nexletol.
Common side effects of Nixletol in company-sponsored studies included high blood pressure and muscle and joint pain. Serious side effects include tendon rupture. Women who are pregnant or breastfeeding should not take Nexletol because it may harm the baby, the FDA said.
In a study of more than 2,200 patients, those in the Nixletol group died of heart disease more often than those in the placebo group. Maybe it’s just a random mismatch, not a big deal, Patel said.
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The company is conducting a large study to determine whether Nexletol can reduce not only cholesterol but also heart attacks and other complications. Results are expected later in 2022. The company estimates that Nexletol could be suitable for 18 million Americans and more than 100 million in other countries.
Michael Valant, 71, of League City, Texas, took Nexletol for 19 months in one study. Valeant, a retired global supply chain manager, had heart surgery a decade ago and had been on stat for years, but not enough. Very common in Asia. Each plant produces up to 15,000 tiny seeds, and then a psyllium husk emerges.
Metamucil psyllium husk powder is rich in soluble fiber. Soluble fiber is known to lower LDL cholesterol. Psyllium comes from a shrub-like plant called Plantago ovata. (Image courtesy of wikimedia.org.
Metamucil is the best known psyllium product, but psyllium is also found in more expensive store brand laxatives.
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Psyllium helps relieve constipation and diarrhea, and is used to treat irritable bowel syndrome and other intestinal problems. Psyllium may also help control blood sugar levels in people with diabetes.
Research shows that psyllium can lower total and LDL (bad) cholesterol levels, which can help reduce the risk of heart disease.
In eight studies of 384 people with high cholesterol who followed a low-fat diet for several weeks, adding psyllium supplements reduced LDL cholesterol by 7 percent.
A study at the Veterans Affairs Medical Center in Lexington, Kentucky found that 197 people who took psyllium for 6 months had 6.7 percent lower LDL cholesterol levels than 51 people in the placebo group.
Solved Refer To The Accompanying Data Table For The Changes
In general, for every 2 grams of soluble fiber added to the diet, LDL cholesterol is reduced by 1 percent or more.
In the above meta-analysis, the dose used to achieve a 7% drop in LDL was 10.2 grams of psyllium per day, which is about 3 teaspoons of uncoated Metamucil per day.
To get cholesterol-lowering benefits, take 1 teaspoon of sugar-free Metamucil with a full glass of water no more than 15 to 30 minutes before a meal.
Psyllium should enter your GI tract at the same time you eat it. Once it reaches your stomach, it begins to dissolve into a gel-like substance. It binds to the bile acids that form cholesterol, thereby “cleansing” the cholesterol. More cholesterol ends up in your bowel movements, and less cholesterol is reabsorbed into your bloodstream.
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A diet rich in natural fiber, such as fruits, vegetables, legumes (beans), and whole grains, is more effective than supplements such as Metamucil in lowering LDL cholesterol.
It is usually a good idea to gradually add Metamucil to your diet. Otherwise, digestive problems such as stomach pain, gas, constipation and diarrhea may occur.
No way. “Don’t think of Metamucil as a one-time thing—it can miraculously clear up cholesterol problems on its own,” comments Kimberly Gomer, director of nutrition and education at the Longevity Center.
“The most effective changes to improve LDL cholesterol and heart health are overall lifestyle changes, especially through dietary changes, including foods rich in natural fiber such as fruits, vegetables, whole grains, and low-fat and low-fat foods.
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Foods high in saturated fat include butter, fatty meats such as red meat, whole-fat and low-fat dairy products, and palm and coconut oils.
Trans fats are found in some margarines and many snack (junk) foods, such as chips, doughnuts, cookies, and crackers. If you see partially hydrogenated fats or oils in the ingredient list on the food label, the food contains trans fat.
Diet and exercise programs have a significant impact on total and LDL cholesterol levels. Peer-reviewed research
In over 4,500 men and women, this lifestyle has been proven to lower total cholesterol by 23% and LDL cholesterol by 23% in 3 weeks.
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A recent study of children with high cholesterol (normal and overweight) showed that program intake reduced LDL cholesterol by 25% in obese adolescents and reduced LDL cholesterol within 2 weeks in adolescents.
“Another lifestyle change not only lowers LDL cholesterol, but also improves many other factors that affect your heart, including blood pressure, blood sugar, triglyceride levels, and body weight. All of these factors add up. Offer the best in heart attack and other cardiovascular problems.” “The best prevention,” concludes Kimberly Gomer, director of nutrition at the Miami Longevity Center. The health resort has been teaching since 1975.
“And you’ll feel better, too,” says nutritionist Kimberly Gomer. “You can’t get all these benefits from a few drops of Metamucil every day.”
This is of course an option. Several studies have shown that psyllium therapy as a meal planning is an effective adjunct to healthy eating advice.
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After 3 months, the scientists found that adding psyllium fiber supplements to a regular diet was enough to have a beneficial effect on metabolic risk factors such as cholesterol and glucose levels. However, psyllium supplementation combined with a healthy, fiber-rich diet “showed significant improvement in risk factors for metabolic syndrome,” the authors concluded.
Phytosterols and stanols are found naturally in plant foods such as vegetables, fruits, whole grains and legumes, but also in fortified foods (everything from orange juice to margarine) and additives such as Cholesterol.
Supplements from these products, such as Cholest-Off, are preferable to fortified foods because of the use of Cholest-Off.
Sterols and stanols instead of the extra calories, fat, salt and sugar found in most phytosterol-rich foods.
Ways To Lower Your Ldl Cholesterol
In the year In 2003, scientists at the University of Toronto studied the effects of a diet plan based on a “combination” of cholesterol-lowering foods.
Eat mostly whole foods that are naturally rich in soluble fiber, but also eat small amounts of phytosterols every day. They found that the diet was statistically effective in lowering LDL cholesterol.
Does Metamucil Lower LDL Cholesterol? Yes. A healthy lifestyle Is a healthy lifestyle better for lowering LDL cholesterol? Absolutely.
Bottom line: “Don’t settle for a piecemeal approach like taking a few teaspoons of Metamucil
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